Frequently Asked Questions: Semaglutide

What is compounded semaglutide?

Compounded semaglutide is an injectable prescription medication that may help individuals with obesity or excess weight (overweight) who also have weight-related health conditions, by promoting weight loss and helping to maintain it.
Compounded semaglutide should be used alongside a reduced-calorie diet and increased physical activity.
Do not use compounded semaglutide in combination with other semaglutide-containing products or any GLP-1 receptor agonist medications.
It is unclear whether compounded semaglutide is safe and effective when combined with other prescription, over-the-counter, or herbal weight loss products.
It is not known if compounded semaglutide is safe to use in individuals who have experienced pancreatitis.
The safety of compounded semaglutide in people with a history of gastroparesis has not been established.
The safety and effectiveness of compounded semaglutide in children under 12 years of age have not been determined.

What should I know about compounded semaglutide?

Compounded semaglutide can cause serious side effects, including:

Thyroid Tumors, including Cancer: Notify your SpadeRX provider if you experience a lump or swelling in your neck, hoarseness, difficulty swallowing, or shortness of breath, as these could be signs of thyroid cancer. In animal studies, compounded semaglutide and similar medications have caused thyroid tumors, including cancer. It is not yet known if compounded semaglutide causes thyroid tumors or medullary thyroid carcinoma (MTC) in humans.
Thyroid Cancer History: Do not use compounded semaglutide if you or your family have a history of medullary thyroid carcinoma (MTC) or if you have a condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Reproductive Considerations: If you are planning a pregnancy, stop using compounded semaglutide at least 2 months prior due to its long half-life.
Potential Eye Condition: A recent study suggests a potential link between semaglutide and an increased risk of a blinding eye disease called non-arteritic anterior ischemic optic neuropathy (NAION). While there is not enough data to confirm this, individuals with diabetes are already at higher risk for NAION, with or without semaglutide. More research is needed to understand the connection, but patients should stay informed and discuss their individual risks with their SpadeRX provider.

How should I use compounded semaglutide?

To begin, carefully read the Instructions for Use and follow the dosing instructions provided by your SpadeRX provider with your compounded semaglutide.
You will start treatment by gradually increasing the dose of compounded semaglutide over a 3 to 4-month period, based on the prescribed dosage plan and your provider’s guidance. You will stay on each dose for at least one month. The syringes included in your prescription are labeled in UNITS, with each syringe containing 100 units. Once you reach your maximum dose, you will continue at that dose unless directed otherwise by your provider.
Use compounded semaglutide exactly as prescribed by your SpadeRX provider. Your provider will give you instructions on how to prepare your dose before you inject for the first time.
Compounded semaglutide is injected just under the skin (subcutaneously) in your stomach (abdomen), thigh, or upper arm. Do not inject into a muscle (intramuscularly) or vein (intravenously). Watch the "How to Inject" video tutorial to learn the proper technique for administering your compounded semaglutide.
Inject compounded semaglutide once a week, on the same day each week, at any time of the day, with or without food.
If you need to change the day you inject, you can, as long as your last dose was given at least 2 days earlier.
Do not use the same injection site each time. Rotate your injection site with each weekly dose. You may use the same area of your body, but make sure the new site is at least one inch away from the previous injection.
Compounded semaglutide can be taken with or without food.
If you accidentally inject too much, you may experience severe nausea, vomiting, and low blood sugar. Seek immediate medical attention at the nearest emergency room if you have these symptoms. After being evaluated, contact your provider.
Once you begin using a vial (after the lid is punctured), the medication expires in 28 days. You may have some leftover medication after 28 days. Please dispose of any excess in your trash and start a new vial. Your subscription provides enough vials to ensure you start a new one each month, around every 4 injections, so your medication stays safe and effective.

If you take too much compounded semaglutide, you may experience severe nausea, vomiting, and low blood sugar. If this happens, go to the nearest hospital emergency room immediately, and contact your care team as soon as possible.

What should I do if I miss a dose of compounded semaglutide?

If you miss a dose of compounded semaglutide and your next scheduled dose is more than 2 days (48 hours) away, take the missed dose as soon as possible.
If your next scheduled dose is less than 2 days (48 hours) away, skip the missed dose and take your next dose on the regular day.
If you miss a dose for more than 2 weeks, contact your care team to discuss how to resume your treatment.

What should I do if I am having surgery?

If you are having surgery, including any procedure with general anesthesia, the American Society of Anesthesiologists (ASA) recommends stopping semaglutide (compounded semaglutide, Ozempic, or Wegovy) and other GLP-1 receptor agonists 1 week prior to elective surgery to minimize the risk of anesthesia-related complications. You may resume the medication once your surgeon gives you the go-ahead. If it has been more than 2 weeks since your last dose, please contact your care team for guidance

How should I store compounded semaglutide?

Store compounded semaglutide in the refrigerator at a temperature between 36°F to 46°F (2°C to 8°C). Keep it in its original carton until use to protect it from light.
Do not freeze compounded semaglutide. If it has been frozen, exposed to light, or stored at temperatures above 86°F, or if it has been out of the refrigerator for 14 days or more, do not use it.
Keep compounded semaglutide and all medications out of the reach of children.

Can I drink alcohol while using compounded semaglutide?

How should I dispose of my medication?

If you no longer need your medication, the safest way to dispose of most old, unused, unwanted, or expired medications (both prescription and over-the-counter) is to drop them off at a drug take-back site, location, or program as soon as possible. You can use the DEA DIVERSION CONTROL DIVISION LOOKUP to find the nearest drug disposal site.
If no drug take-back sites or programs are available in your area, and there are no specific disposal instructions (such as flushing) in the medication guide or package insert, visit the FDA’s Disposal of Unused Medicines page for more information, or follow these simple steps to dispose of most medications at home:

Mix the medication (liquid or pills; do not crush tablets or capsules) with an unappealing substance like dirt, cat litter, or used coffee grounds.
Place the mixture in a sealed container, such as a plastic bag.
Throw the sealed container in your household trash.
Remove all personal information from the prescription label of empty medication bottles or packaging, then dispose of or recycle the empty containers.

How do I dispose of used syringes?

After using a syringe, immediately dispose of it in a safe, hard-sided container with a secure lid, such as a food storage container or an empty laundry detergent canister. Do not reuse syringes or attempt to recap them, as this may lead to accidental needle sticks. When the container is about three-quarters full, take it to your local pharmacy or find an authorized disposal site near you for proper disposal. Syringes should never be discarded loose in the trash, toilet, or recycling bin.
You can find a local disposal solution by visiting the following website: Safe Needle Disposal This resource helps you locate authorized sites near you for the safe disposal of used syringes and other sharps.

What are the possible side effects of compounded semaglutide?

The most common side effects of compounded semaglutide include nausea, diarrhea, vomiting, abdominal pain, headache, indigestion, upset stomach, dizziness, bloating, gas, stomach flu, runny nose, sore throat, belching, constipation, fatigue, and heartburn.
Kidney problems (kidney failure): In individuals with existing kidney issues, dehydration caused by diarrhea, nausea, and vomiting can worsen kidney function. It is important to stay hydrated to help prevent dehydration.
Gallbladder issues: Compounded semaglutide may lead to gallbladder problems, including gallstones, some of which may require surgery. Contact your SpadeRX provider immediately if you experience symptoms of gallbladder problems, such as:

Pancreatitis (inflammation of the pancreas): If you experience severe, persistent stomach pain (abdomen) that does not go away, with or without vomiting, stop using compounded semaglutide and seek medical attention immediately. The pain may extend from your abdomen to your back.
Increased heart rate: Compounded semaglutide can cause an increased heart rate while at rest. Inform your SpadeRX provider if you experience a racing or pounding heart that lasts for several minutes.
Severe allergic reactions: If you experience any symptoms of a serious allergic reaction, such as swelling of the face, lips, tongue, or throat, dizziness or fainting, trouble breathing or swallowing, a very rapid heartbeat, or a severe rash/itching, stop using compounded semaglutide immediately and seek urgent medical help by calling 911 or going to the Emergency Room.
Increased risk of low blood sugar (hypoglycemia) in patients with type 2 diabetes: Compounded semaglutide can increase the risk of low blood sugar, particularly for patients who also take medications like sulfonylureas or insulin to treat type 2 diabetes. Low blood sugar can be both a serious and common side effect in these patients. It’s important to discuss with your SpadeRX provider how to recognize and manage low blood sugar. Make sure to check your blood sugar levels before starting and while using compounded semaglutide. Symptoms of low blood sugar may include:

Dizziness or light-headedness
Blurred vision
Anxiety, irritability, or mood changes
Sweating
Slurred speech
Hunger
Confusion or drowsiness
Shakiness
Weakness
Headache
Fast heartbeat
Feeling jittery

Vision changes in patients with type 2 diabetes: If you notice any changes in your vision while using compounded semaglutide, inform your SpadeRX provider. Diabetes can lead to a condition called diabetic retinopathy, which damages blood vessels in the retina and can cause scarring. As the scarring progresses, it can pull on the retina and cause retinal detachment, a serious condition.
Increased heart rate: Compounded semaglutide can raise your heart rate while at rest. Your SpadeRX provider should monitor your heart rate during treatment. If you feel your heart racing or pounding in your chest for several minutes, contact your SpadeRX provider immediately.
Depression or thoughts of suicide: Be alert to any changes in your mood, behavior, thoughts, or feelings. If you experience any new or worsening mental health symptoms, or if you are concerned about your mental health, contact your SpadeRX provider right away.

If you experience any side effects that bother you or don't go away, talk to your SpadeRX provider. For medical advice regarding side effects, contact your SpadeRX provider. You can also report any adverse effects of prescription drugs to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088.

What can I do if I experience nausea, vomiting, or stomach discomfort?

Slow Eating and Smaller Portions: Eat slowly and consume smaller, more frequent meals, which can reduce nausea.
Avoid Rich or Fatty Foods: Foods high in fat or heavy spices can exacerbate gastrointestinal symptoms. Focus on simpler, less oily meals.
Stay Hydrated: Drinking water throughout the day, especially when symptoms occur, can ease nausea and prevent dehydration if vomiting occurs.
Consider Ginger or Peppermint: Ginger tea, ginger candies, or peppermint can sometimes alleviate mild nausea naturally.”

What can I do to relieve constipation or diarrhea?

For Constipation:

Increase Fiber Intake Gradually: Add fiber-rich foods like fruits, vegetables, and whole grains to the diet, but gradually, as sudden increases in fiber can lead to bloating or discomfort.
Stay Active: Light physical activity, such as walking, can stimulate bowel movements and help with constipation.
Stay Hydrated: Drinking enough water daily supports healthy digestion and can relieve constipation.
Consider a Stool Softener if Needed: If constipation remains an issue, try using a mild stool softener or fiber supplement to help relieve symptoms.

For Diarrhea:

Avoid Trigger Foods: Caffeine, dairy, fatty foods, and artificial sweeteners can sometimes trigger or worsen diarrhea, so it may help to avoid or reduce these.
Focus on Bland Foods: Try eating easy-to-digest foods like bananas, rice, applesauce, and toast (the "BRAT" diet) until the symptoms subside.
Electrolyte Balance: Drinking water with added electrolytes (like oral rehydration solutions) can prevent dehydration if diarrhea is persistent.
Gradually Reintroduce Foods: Once symptoms improve, you can slowly reintroduce more foods, monitoring any sensitivity.

How can I address dizziness or fluctuations in energy levels?

Adjust Physical Activity Accordingly: Be mindful of sudden movements or overexertion if you’re feeling dizzy and rest when needed.
Regular Meals and Hydration: Consistent, balanced meals and regular hydration can help stabilize energy and blood pressure levels.
Avoid Alcohol: Alcohol can lower blood sugar and exacerbate dizziness, so it’s best to limit or avoid it, especially around dosing times.

How long will I need to stay on medication?

The length of time an individual remains on semaglutide can vary depending on factors such as their response to the medication, weight management goals, and overall health. At BodyRx, SpadeRX professionals regularly evaluate progress and determine whether to continue or discontinue the medication based on the individual's specific response.

Additional Information:

Medications are sometimes prescribed for purposes other than those listed in the Medication Guide. Do not use compounded semaglutide for conditions other than what it was prescribed for. Do not share your medication with others, even if they have the same condition, as it may cause harm. For additional information about compounded semaglutide, ask your pharmacist or SpadeRX provider for details intended for health professionals.

How much weight can I lose with weight loss medications?

As a science-backed weight loss program that’s been developed by experts, your unique treatment plan is designed to support healthy, sustainable results. Because everyone’s weight loss journey is different, the timeline for results may vary from person to person. In general, it’s important to incorporate healthy lifestyle and wellness changes such as:

When will I see results?

Remember, results aren’t instant. Because everyone’s weight loss journey is different, the timeline for results may vary from person to person. Along with medication, it’s important to get proper sleep, nutrition, movement, and water for the best results.

How are compounded GLP-1s sourced?

Ingredients are sourced from FDA-regulated suppliers, and the treatments are compounded in FDA-regulated facilities.